Androgens enhance male urinary tract infection severity in a new model
PD Olson, KA Hruska, DA Hunstad - Journal of the American …, 2016 - journals.lww.com
Urinary tract infections (UTIs) occur predominantly in females but also affect substantial male
patient populations; indeed, morbidity in complicated UTI is higher in males. Because of
technical obstacles, preclinical modeling of UTI in male mice has been limited. We devised a
minimally invasive surgical bladder inoculation technique that yields reproducible upper and
lower UTI in both male and female mice, enabling studies of sex differences in these
infections. Acute uropathogenic Escherichia coli (UPEC) cystitis in C57BL/6 and C3H/HeN …
patient populations; indeed, morbidity in complicated UTI is higher in males. Because of
technical obstacles, preclinical modeling of UTI in male mice has been limited. We devised a
minimally invasive surgical bladder inoculation technique that yields reproducible upper and
lower UTI in both male and female mice, enabling studies of sex differences in these
infections. Acute uropathogenic Escherichia coli (UPEC) cystitis in C57BL/6 and C3H/HeN …